pentobarbital will enhance the amount or influence of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of ivosidenib with strong CYP3A4 inducers decreased ivosidenib plasma concentrations.pentobarbital and daridorexant both of those improve sedation. Modify Therapy/Keep trac